Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors.
نویسندگان
چکیده
Sirtuins regulate a variety of biological pathways and inhibitors of sirtuins have been actively pursued as tool compounds to study sirtuin biology and as potential therapeutics. Here we demonstrate that thiomyristoyl peptides are potent and cell-permeable inhibitors of Sirt6, one of the seven human sirtuins, and will serve as the starting point for the development of more specific Sirt6 inhibitors.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 38 شماره
صفحات -
تاریخ انتشار 2014